Remission Phase Study
As it has been established that differences across centres are maintained over three years, and as it has been found that between-centre differences in glycaemic control are present soon after onset of diabetes, the Hvidøre Study Group decided to focus on the early course of the disease in future studies. The group has therefore started a new study to investigate the remission phase in children and adolescents with newly diagnosed diabetes.32,33
In this prospective multicentre survey, it will be possible to investigate whether the differences between centres in glycaemic control and hypoglycaemia are associated with the patients' genetic or immunological background or are related to other factors such age, ketoacidosis, and initial insulin treatment.
In addition, the study will show the effect of the initial insulin management on the preservation of the residual beta-cell function.
32. Holl RW, Swift P, Hougaard P et al. Clinical characteristics of newly diagnosed type 1 diabetes mellitus in children and adolescents from 19 centres. Hvidøre Study Group on Childhood Diabetes. J Pediatr Endocrinol Metab 2001;14(Suppl 3):1033, Abstract No. OP-17.
33. Swift PGF, Holl RW, Mortensen HB et al. Influence of initial presentation and insulin treatment on metabolic control at one month after diagnosis in an international cohort of young people with type 1 diabetes. Hvidøre Study Group on Childhood Diabetes. J Pediatr Endocrinol Metab 2001;14(Suppl 3):1072, Abstract No. PP-150.